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Pharmazeutische- und kosmetischezusammensetzungen enthaldend serinproteasen aus kabeljau und deren pharmazeutische und kosmetische verwendung Pharmaceutical and cosmetic compositions enthaldend serine proteases from cod and pharmaceutical and cosmetic use translated from German DE T2.

Fisch-Serinproteinase, die aus Kabeljau gewonnen werden kann, zur Verwendung als ein Medikament. Fish serine proteinase obtainable from Cod for use as a medicament.

A proteinase according to claim 1 which is selected from the group consisting of a trypsin, a chymotrypsin and any mixture thereof. Proteinase nach Anspruch 1 oder 2, die nicht multifunktionell ist.

A proteinase according to claim 1 or 2 that is not multifunctional. A proteinase according to any of claimswhich is derived from Atlantic cod. Proteinase nach Anspruch 1, bei der es sich um ein Trypsin aus dem atlantischen Kabeljau handelt. A proteinase according to claim 1, wherein it is a trypsin from Atlantic cod. A proteinase according to Behandlung von Krampfadern droppers 4, selected from the group consisting of chymotrypsin A and chymotrypsin B.

A method for removing dead or nonseparated skin from otherwise Thrombophlebitis tromboass skin by use of a proteinase of claim 1. Use of a fish serine proteinase obtainable from Cod for removing dead or nonseparated skin from otherwise healthy skin. Use according to any Behandlung von Krampfadern droppers of claimswherein the fish serine proteinase is a proteinase according to any of claims Pharmazeutische Zusammensetzung umfassend eine Fisch-Serinproteinase, Behandlung von Krampfadern droppers aus Kabeljau gewonnen werden kann.

A pharmaceutical composition comprising a fish serine proteinase obtainable from Cod. Zusammensetzung nach Anspruch 16, wobei die Fisch-Serinproteinase eine Proteinase nach einem der 2—11 ist. The composition of claim 16 wherein the fish Behandlung von Krampfadern droppers proteinase is a proteinase according to any of The composition of claim 16 or 17, wherein it is a composition for topical use.

Zusammensetzung nach Anspruch 18, bei der es sich um ein Hydrogel handelt. The composition of claim 18, wherein it is a hydrogel. The composition of claim 19, further comprising a polyvalent alcohol including glycerol. Zusammensetzung nach Anspruch 16, umfassend eine weitere pharmazeutisch aktive Verbindung. The composition of claim 16 comprising a further pharmaceutically active compound.

Kosmetische Zusammensetzung umfassend eine Fisch-Serinproteinase, die aus Kabeljau gewonnen werden kann. Cosmetic composition comprising a fish serine proteinase obtainable from Cod. Zusammensetzung nach Anspruch 22, wobei die Fisch-Serinproteinase eine Proteinase nach einem der 2—11 ist.

The composition of claim 22 wherein the fish serine proteinase is a proteinase according to any of Zusammensetzung nach Anspruch 22, bei der es sich um ein Hydrogel handelt. The composition of claim 22, wherein it is a hydrogel. Read more composition of claim 22, further comprising a polyvalent alcohol including glycerol.

Zusammensetzung Behandlung von Krampfadern droppers Anspruch 22, umfassend eine weitere, kosmetisch aktive Verbindung.

The composition of claim 22 comprising a further cosmetically active compound. Die vorliegende Erfindung bezieht sich ihrem weitesten Aspekt auf das Gebiet der Behandlung und Vorbeugung von Krankheiten und auf den Kosmetikbereich, insbesondere die pharmazeutische und kosmetische Verwendung von Serinproteinasen, die aus Fisch gewonnen werden.

The present invention relates its broadest aspect to the field of treatment and prevention of diseases and the cosmetics sector, particularly the pharmaceutical and cosmetic use of serine proteinases derived from fish.

Die US Patentnummern 4. The US patent numbers 4, and 4, to give a mixture of exo- and endopeptidases, which are isolated from Antarctic krill Euphausia superba Behandlung von Krampfadern droppers, and use this mixture as a cleaning solution.

The US Patent Behandlung von Krampfadern droppers. EP-A shows the use Behandlung von Krampfadern droppers krill enzymes to dissolve blood clots.

However, all of these references refer to impure or poorly characterized materials. A purified peptidase or mixture of purified peptidases is desirable to provide pharmaceutically useful agents. Furthermore, no indication was found useful in the purified peptidases or a mixture of purified peptidases for the treatment of diseases such. As arthritis, arthritis, bursitis, osteoarthritis, Behandlung von Krampfadern droppers arthritis, septic arthritis, phlebitis, Behandlung von Krampfadern droppers, rash, psoriasis or infectious diseases are.

Dieser Antrag bezieht sich ebenfalls auf Methoden der Reinigung von multifunktionalen Enzymen und auf pharmazeutische, kosmetische und andere Anwendungen multifunktionaler Enzyme. This application also relates to methods of purification of multifunctional enzymes and pharmaceutical, cosmetic and other applications of multifunctional enzymes.

Moreover, it is in the trypsins and chymotrypsins obtained from cod to no multifunctional enzymes. Endometriose, Krampf gleicher best-known activity in each of trypsin proteases and chymotrypsin proteases.

The main objective of the present invention is the use of cod derived trypsins and chymotrypsins in pharmaceutical compositions or medicaments for local and topical application for the treatment of internal diseases and disorders and for the Behandlung von Krampfadern droppers use of such enzymes. The topical use for the local treatment of internal disorders, without the enzyme must penetrate into open wounds or mucous tissue, was found to be surprisingly effective as described in the accompanying examples.

This is in contrast to learning content according to the prior art for the related use of other enzymes, for example, the multifunctional hydrolase of krill enzyme is injected for the treatment of local pain. Another object of the present invention is the use of products derived from cod trypsins and chymotrypsins for use in pharmaceutical compositions or medicaments for the transport of other protein or non-protein active compounds through the skin for local and topical application for the treatment of internal diseases and disorders.

Es wurde festgestellt, dass solche Serinproteinasen pharmazeutisch ausgesprochen aktiv gegen eine Vielzahl von Krankheiten sind.

It has been found that such serine proteinases are pharmaceutically very active against a variety of diseases. Accordingly, in a first aspect the present invention relates to a fish serine proteinase for use as a Behandlung von Krampfadern droppers. In this context, particularly useful proteinases click at this page trypsins and chymotrypsins that are cod, such as the Atlantic cod, won.

In still further aspects, the invention provides the use of a fish serine proteinase in the manufacture of a medicament for removing dead or nonseparated skin from otherwise healthy skin and continue reading use of fish serine proteinase in the manufacture of a medicament for the treatment and prevention of a disease in, whose origin is involved in receptor-mediated binding before.

Accordingly, the invention also provides a process for the preparation of a purified preparation on a commercial scale of cod trypsin isoenzymes is provided, comprising the steps of i preparation of an aqueous extract of cod viscera ii subjecting the aqueous extract one or more chromatography steps, including a step of affinity chromatography using a p-aminobenzamidine-ligand and iii desorbing and eluting the trypsin binding to the p-aminobenzamidine affinity ligand and a purified preparation on a commercial scale of cod trypsin.

The present invention provides the use of products derived from cod trypsins or other related trypsins or serine proteinases such as Chynotrypsinen, which are derived from animals, especially aquatic animals such as fish including cod, available in a variety of medical and cosmetic contexts. The term "enzyme" as used herein, unless otherwise specified, is used to refer to an active enzyme. The term "trypsin and other related peptidases" means here peptidases from trypsin-type EC 3.

The term "chymotrypsin and other related peptidases" refers to peptidases of the chymotrypsin type EC 3. In particular, the enzymes according to the invention Behandlung von Krampfadern droppers the treatment of pain, acute or chronic inflammation, arthritis, arthritis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, septic arthritis, fibromyalgia, systemic lupus eyrthematosus, phlebitis, eczema, rash, psoriasisacne, wounds and candidiasis are applicable.

In applicable embodiments, cod trypsin or cod chymotrypsin or a mixture of these enzymes in a pharmaceutical composition containing purified peptidase or mixture of purified peptidase and einpharmazeutisch suitable solvent or carrier, in the first place, but not limited to, hydrogel, locally or topically to the affected area.

In addition, the enzymes are applicable for the treatment of viral infections such as herpes infections, caused by fungi, bacteria, or parasitic infections, including colitis, ulcers, hemorrhoids, corneal scarring, dental plaque and immune disorders Behandlung von Krampfadern droppers autoimmune diseases. Enzymes that are similar structurally cod gained trypsins and chymotrypsin Behandlung von Krampfadern droppers have the same utility as the cod enzymes.

These trypsin and chymotrypsin enzymes are particularly applicable for the treatment of arthritis, arthritis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, septic arthritis and phlebitis. In addition, the enzymes are applicable for the treatment of viral infections such as herpes infections, caused by fungi, bacteria, or parasitic infections, including colitis, ulcers, hemorrhoids, Behandlung von Krampfadern droppers, dental plaque, acne, wounds, candidiasis and immune disorders including Behandlung von Krampfadern droppers diseases.

Insbesondere betrifft die Erfindung die medizinischen, pharmazeutischen und kosmetischen Anwendungen von Trypsinen, die aus atlantischem Kabeljau oder anderen Tieren gewonnen werden. In particular, the invention relates to the medical, pharmaceutical and cosmetic applications of trypsins derived from Atlantic cod or other animals.

Es Behandlung von Krampfadern droppers drei besonders wichtige Isoenzyme von Trypsin Behandlung von Krampfadern droppers atlantischem Kabeljau, die gereinigt und charakterisiert wurden.

There are three major isoenzymes of trypsin particularly in Atlantic cod that have been purified and characterized. All three isoforms of Behandlung von Krampfadern droppers trypsin have a similar molecular mass of approximately 24 kDa. Die Erfindung betrifft auch die medizinischen, pharmazeutischen und kosmetischen Anwendungen von Chymotrypsinen, die aus atlantischem Kabeljau oder anderen Tieren gewonnen werden. The invention also relates to the Behandlung von Krampfadern droppers, pharmaceutical and cosmetic Behandlung von Krampfadern droppers chymotrypsins derived from Atlantic cod or other animals.

Es gibt drei besonders wichtige Isoenzyme von Chymotrypsin in atlantischem Kabeljau, die gereinigt und charakterisiert wurden. There are three major isoenzymes of chymotrypsin particularly in Atlantic cod that have been purified and characterized. Both isoforms of cod chymotrypsin have a similar molecular mass of approximately 26 kDa.

Cod trypsins and chymotrypsin are isolated from cod viscera except liver, spleen and roe and cleaned. The inventors have recognized the methods described above as applicable to which is made in a commercial scale production of cod trypsins and chymotrypsins. After separation of the crude extract solution and residual offal, the extract is clarified by sedimentation or filtration. Subsequently, the cod trypsin by affinity chromatography, preferably purified by affinity chromatography aminobenzamidine, and chymotrypsin by hydrophobic interaction chromatography, preferably by phenyl-Sepharose chromatography.

Here, the production refers to commercial scale of cod trypsin and unteren Gliedmaßen, die nicht sein kann, reliable and effective method to click at this page production of parts in the order of between 1 and 10 g or more, and 10 - allow g or more.

A suitable concentration of trypsin activity is between 0. The invention Behandlung von Krampfadern droppers provides a pharmaceutical composition comprising the cod trypsins and related peptidases and-a pharmaceutically acceptable solvent or carrier means includes. The invention further Behandlung von Krampfadern droppers a means before, which are intended for certain diseases, wherein effective amounts of purified enzymes as described above and b compositions or substances for use in these methods are used, and c pharmaceutical compositions containing effective contain amounts of enzymes for use in these methods, and d uses of enzymes or enzyme compositions for the manufacture of a medicament for use in such methods.

Syphilis und Infektionen durch E. Dissolve blood clots, wherein the amount of the administered enzyme preferably represents an effective resolution for the amount of blood clots. Die Zusammensetzung der Erfindung kann auch Behandlung von Krampfadern droppers verwendet Behandlung von Krampfadern droppers, abgestorbene oder abweichende Zellen zu entfernen. The composition of the invention can also be used to remove dead or divergent cells. The invention provides topical cosmetic and medical compositions comprising, consisting of, purified cod trypsin, chymotrypsin or other related peptidases as described above, and gel, cream or Behandlung von Krampfadern droppers compositions.

The invention provides also a means for the treatment and preventive preventing with cell-cell or cell-virus adhesion Krampfadern Cellulite-Behandlung syndromes, above, which comprises administering an effective for the click amount of the cod trypsins or chymotrypsins or related peptidases for removal or deactivation of a cell or viral acceptor or receptor adhesion component that is involved in cell-cell or cell-virus adhesion, provides for b compositions or substances for use in such methods, c pharmaceutical compositions containing effective amounts of enzyme for use in such methods and the d the use of enzyme compositions for the manufacture of a medicament Behandlung von Krampfadern droppers use in such methods.

In general, this syndrome affects inflammation, arthritis, arthritis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, septic arthritis, phlebitis, eczema, rash, psoriasis, acne, wounds, candidiasis and immune disorders including autoimmune diseases, shock, tumor metastasis, transplant rejection, or microbial infections.

Preferably, a microbial infection is treated or prevented and the microbial infection is herpes, HIV, hepatitis or papilloma virus infection, an infection which triggers colitis or diarrhea, a Candida infection, such as an oral, vaginal or esophageal Candida infection, a cold or influenza infection, by Staphylococcus, Streptococcus, Klebsiella, Pseudomonas, Haemophilus or E. In a preferred embodiment, a spray, ointment or wash is applied to a body orifice involved in sexual Behandlung von Krampfadern droppers, for Behandlung von Krampfadern droppers, to prevent the transmission of HIV or hepatitis.

In a further preferred embodiment, the cod trypsin or related peptidases to the upper Krampfadern als Eier behandeln tract, for example, by aerosol, applied to the transmission of a common cold virus, such as the rhinovirus or coronavirus to inhibit or prevent.

In one aspect, the method reduces the external treatment of a tissue, a body fluid or cell composition to remove cell adhesion components, the immune rejection of tissue, body fluid or cell composition that is Behandlung von Krampfadern droppers from one person to another. In another aspect, such treatments remove or disable the cell adhesion components that are on the treated tissue, body fluid or cell composition which is affected by a microbial infection, found.

In the treatment or prophylactic prevention of septic shock or toxic shock syndrome by administering the cod trypsin or related peptidases include the Behandlung von Krampfadern droppers routes of administration, a systemic administration. In vaginal infections associated with shock, vaginal irrigations, creams, gels or suppositories may be used as the mode of administration. In the treatment or prophylactic prevention Behandlung von Krampfadern droppers pain, inflammation, acute or chronic inflammation, arthritis, arthritis, bursitis, osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, septic arthritis, fibromyalgia, systemic lupus eyrthematosus, phlebitis by administering the cod trypsin or related peptidases, appropriate routes of administration include without limitation creams, gels or suppositories, in particular Behandlung von Krampfadern droppers not Behandlung von Krampfadern droppers to hydrogels containing glycerol or other polyols, a.