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This document contains side effect information about estradiol. Some of the dosage forms listed on this page may not apply Thrombophlebitis und Hunger the brand name Vivelle-Dot. Along with its needed effects, estradiol the active ingredient contained in Vivelle-Dot may cause some more info effects.
Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking estradiol:. Get emergency help immediately if any of the following symptoms of overdose occur while taking estradiol: Some side effects of learn more here may occur that usually do not need medical attention.
These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. For Healthcare Professionals Applies to estradiol: Cases of oral pigmentation and ischemic colitis have been reported rarely. Gastrointestinal side effects have included nausea, abdominal cramps, bloating and vomiting.
Some studies have demonstrated a 2 to 4 fold increase in gallbladder disease in postmenopausal women taking estrogen therapy. Cholestatic jaundice, pancreatitis, and enlargement of hepatic hemangiomas have been reported.
Postmarketing experience with the vaginal ring has included a few cases of bowel obstruction and vaginal ring use. Postmarketing side effects with Vivelle-Dot include nausea, vomiting, abdominal cramps, bloating, cholelithiasis and diarrhea. Oncologic side effects have included reports of an increased Thrombophlebitis und Hunger of endometrial carcinoma in patients with an intact uterus and less persuasively, with an increased risk of breast cancer. A number of studies have suggested that the risk of endometrial carcinoma is removed or delayed by the administration of progestins in combination with estrogen therapy.
Thrombophlebitis und Hunger increased risk of breast cancer due to use of estrogens is controversial. Several studies have suggested that long-term estrogen therapy may be associated with a slightly increased risk of breast cancer. Meta analysis of 51 studies epidemiological data supports Thrombophlebitis und Hunger modest risk increase associated with long-term hormone replacement therapy HRT.
That study, however, examined use of a variety of estrogen preparations of which estradiol was the most frequently prescribed. In addition, women who took progestins did not demonstrate a decreased risk of breast cancer and may even have been at higher risk. The Toronto Thrombophlebitis und Hunger Cancer Study Thrombophlebitis und Hunger reported that women who receive unopposed conjugated estrogens for less than 15 years are not at increased risk of breast cancer.
In that study, an increase in the risk of breast cancer for women who used conjugated estrogens for more than 15 years was not ruled out. The Case-Control Surveillance Study has reported that there is "no evidence that the use of unopposed conjugated estrogens increases the risk of breast cancer, even after long duration of use Thrombophlebitis und Hunger long latent intervals, but the possibility of a modest increase less than a doubling could not be excluded.
In that study, greater risk was associated with advanced age and prolonged duration of hormonal therapy. A study of middle-aged women in the Puget Sound area concluded that "on the whole, the use of estrogen with progestin HRT [hormone replacement therapy] does not appear to be associated with an increased risk of breast cancer in middle-aged women.
The relative risk of invasive carcinoma with a favorable prognosis for current users adjusted for age and other risk factors was 4. The reported effects of estrogens on cardiovascular activity are variable. Alterations in lipid profiles in treated women are thought to be responsible for reducing cardiovascular risks. Data suggest estrogen use may increase blood pressure, particularly in patients receiving high doses, decrease blood pressure, or result in no change. In addition, noncontraceptive use of estrogens in young women particularly smokers may substantially increase the risk of nonfatal myocardial infarction.
Other studies have concluded that no increased risk of myocardial infarction exists. Combination therapy with a progestin may Thrombophlebitis und Hunger also decreased coronary risk.
However, the extent of Thrombophlebitis und Hunger reduction with combination therapy has not been determined. Data are available that suggest combination therapy does not reduce the overall rate of coronary heart disease in postmenopausal women with established coronary disease.
Postmarketing side effects with Vivelle-Dot include deep vein thrombosis, pulmonary embolism and thrombophlebitis. Metabolic side effects have included reports Thrombophlebitis und Hunger generally favorable alterations in plasma lipid profiles. Estrogen therapy may have led to increased serum triglyceride levels resulting in pancreatitis in patients with Thrombophlebitis und Hunger lipoprotein metabolic defects.
Metabolic adverse effects such as hypercalcemia have occurred in patients with breast cancer and bone metastases. Endocrine side effects have included increased levels of thyroxin-binding globulin which led to increased total thyroid serum levels and a decreased in resin uptake of T3. Free thyroid hormone levels remained unchanged. Other endocrine effects have included decreased fasting plasma glucose.
General side effects have included fluid retention and mastodynia. Alterations in libido have occurred. Postmarketing experience with the vaginal ring has included a few cases of toxic shock syndrome.
Postmarketing side effects with Vivelle-Dot include decrease in weight, reduced carbohydrate tolerance and edema. Hepatic side effects have included reports of focal nodular hyperplasia, liver cell adenomas, hepatic hemangiomas, and Thrombophlebitis und Hunger hepatocellular carcinomas. Aggravation of porphyria has been reported. Postmarketing side effects with Vivelle-Dot include abnormal liver function tests. Many of the reports of hepatic tumors have Thrombophlebitis und Hunger in women taking long-term oral Thrombophlebitis und Hunger. However, some tumors have been reported in Thrombophlebitis und Hunger taking isolated estrogen therapy.
Hematologic side effects have included hypercoagulability and an increase in venous thromboembolism. The clinical significance of such hypercoagulability in postmenopausal women taking estrogens has not been determined. Ocular side effects have Thrombophlebitis und Hunger alterations in corneal curvature and contact lens discomfort.
Retinal vascular thrombosis has been reported. Postmarketing side effects with Vivelle-Dot include intolerance to contact lenses.
Hypersensitivity side effects have included reports of reactions including anaphylaxis. Some reports Thrombophlebitis und Hunger implicated the dyes contained in some conjugated estrogen formulations. Urticaria and angioedema have also been reported. Postmarketing reports concerning a transdermal product Climara have included a few Thrombophlebitis und Hunger in which there were a combination of Geschichte der Krankheit Krampfadern Extremität Krankheit symptoms of generalized hives or rash Thrombophlebitis und Hunger swelling of the throat or eyelid edema.
Other side effects have included reports of Thrombophlebitis und Hunger possible increase in the risk of Thrombophlebitis und Hunger breast disease" by as much as twofold. Postmarketing side effects with Vivelle-Dot include breast enlargement and pain, nipple discharge, fibrocystic breast changes and breast cancer. Psychiatric side click the following article have included case reports of rapid mood cycling in patients with severe depression.
Postmarketing side effects with Vivelle-Dot include nervousness, affect liability and irritability. Nervous system side effects Krampfadern es included dementia, dizziness, mental depression, headache, nervousness, irritability exacerbation of epilepsy and new onset or exacerbation of migraine headaches.
A case of chorea has been reported in association with estrogen therapy. Dermatologic side effects have included chloasma or melasma, which did not always resolve following discontinuation of estrogen therapy.
Scalp hair loss, hirsutism, erythema nodosum, and hemorrhagic eruptions have occurred. Postmarketing side effects with Vivelle-Dot include Thrombophlebitis und Hunger multiforme, pruritus, purpura and rash.
Genitourinary side effects have included abnormal uterine bleeding and dysmenorrhea. In some cases, this was bleeding related to endometrial carcinoma.
In addition, estrogens have increased the size of preexisting Thrombophlebitis und Hunger leiomyomata. Postmarketing experience with the vaginal ring has included a few cases of ring adherence to the vaginal wall, making removal difficult.
Postmarketing side effects with Vivelle-Dot include vaginal hemorrhage, abnormal withdrawal bleeding or flow, breakthrough bleeding, spotting, uterine leiomyomata, vaginitis, vaginal discharge, ovarian cancer and endometrial hyperplasia. Musculoskeletal side effects have included arthralgias. Postmarketing side effects Thrombophlebitis und Hunger Vivelle-Dot include leg cramps. Boston Collaborative Drug Surveilance Program "Surgically confirmed gallbladder disease, venous Thrombophlebitis und Hunger, and breast tumors in relation to postmenopausal estrogen therapy.
An Pressotherapy für die Beine mit Krampfadern pathology review supporting original risk estimate. Report of a large case-control Thrombophlebitis und Hunger. Rancho Bernardo, Calif, revisited.
Belchetz PE "Hormonal treatment of postmenopausal women. Possible association with estrogen therapy. Boschetti C, Cortellaro M, Nencioni T, Bertolli V, Della Volpe A, Zanussi C "Short- and long-term effects of hormone replacement therapy transdermal estradiol vs oral conjugated equine estrogens, combined with medroxyprogesterone acetate on blood coagulation factors in postmenopausal women.
Oppenheim G "A case of rapid mood cycling with estrogen: Julian TM "Pseudoincontinence Thrombophlebitis und Hunger to unopposed estrogen replacement in the surgically castrate premenopausal female.
Some side effects of Vivelle-Dot may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is Thrombophlebitis und Hunger reference resource designed as supplement to, and not a substitute for, the expertise, skillknowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug click the following article combination thereof in no way Thrombophlebitis und Hunger be construed to indicate safety, effectiveness, or appropriateness for any given patient.
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