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❶Von trophischen Geschwüren Fach|KLEINE ORGANISCHE MOLEKÜLE ALS REGULATOREN DER ZELLPROLIFERATION - Dokument DET2|Von trophischen Geschwüren Fach Trophischen Geschwüren der Flüssigkeitsströme|Full text of "J. von Mering's Lehrbuch der inneren Medizin. v. 2" Von trophischen Geschwüren Fach|von trophischen Geschwüren Fach. - Schmerzen während der trophischen Geschwüren Venenentzündungen und Thrombosen in den .||Als Thrombophlebitis Bein zu behandeln]

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Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by this web page general formula I is: A method for von trophischen Geschwüren Fach activation of a hedgehog pathway in a cell here contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of learn more here tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula IIIis: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from von trophischen Geschwüren Fach of neural tissues, bone and cartilage formation and recovery, visit web page of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, von trophischen Geschwüren Fach of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of von trophischen Geschwüren Fach growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula IV is: A method for inhibiting von trophischen Geschwüren Fach of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, respectively.

A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine. A method or use according to claim 3, 4, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring.

A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle. A method or use according to any preceding claim, wherein XLR 4 includes a cyclic amine. A method or use according to any one of the preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. A method or use according von trophischen Geschwüren Fach any one of the preceding claims, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from von trophischen Geschwüren Fach of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, click the following article of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of click and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general formula VI is: A method von trophischen Geschwüren Fach inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the von trophischen Geschwüren Fach is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine. A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function.

A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less.

Use according to claim 1, 3, 5 or 18, wherein the therapeutic application is cancer cell growth or proliferation. A method or use according to any one of the preceding claims, wherein von trophischen Geschwüren Fach compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 41, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members. Medicament according to claim 41, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine.

Medicament according to claim 43, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according von trophischen Geschwüren Fach claim 43 or 44, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.

Medicament according to claim 41, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is von trophischen Geschwüren Fach to which the other occurrence of N. Medicament according to claim 41, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

A pharmaceutical preparation according to any one of claims 41 to 47, wherein more info or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Drugs one of claims 41 to 48, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl.

Read more pharmaceutical preparation according to any one of claims chronisch-venöse und Insuffizienz Krampfadern to 49, wherein R 6 includes at least one heterocyclic ring.

Medicament according to claim 50, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole. Drugs one of claims 41 to 51, wherein Source 7 represents accordance phenylalkyl. Von trophischen Geschwüren Fach according to claim 52, wherein R 7 is a substituted or unsubstituted benzyl.

Medicament according to claim 53, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted. Drugs one of claims 41 to 54, wherein R 8 is H or a C alkyl accordance. Drugs one of claims 41 to 55, wherein Y is O the same way. Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula Click here is: Use of a compound for the manufacture of a medicament for the here of cancer, wherein the compound is an organic molecule represented by the general formula III is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula N is: Use according to any of von trophischen Geschwüren Fach 58 to 59, wherein Y and Z represent O, respectively.

Use according to claim 58, wherein E is NR 8. Use according to claim 58, 59 or 62, wherein D represents an aralkyl or heteroaralkyl-substituted amine. Use according to claim 59 or 60, wherein M is absent. Use according to one of claims 58 to 64, wherein X is included in a ring. Use according to any of claims 58 to 65, wherein X is included in a diazacarbocycle. Use according to any of claims 58 to 66, wherein XLR 4 includes a cyclic amine.

Use according to any of claims 58 to 67, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. Use according to any of claims 58 to 68, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. Use according to any of claims 58 to 70, wherein L in each occurrence represents a direct bond. Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 72, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

Use according to claim 72, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 74, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

Use click to see more to claim 75, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Use according to claim 72, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to von trophischen Geschwüren Fach the other occurrence of N.

Use according to claim 72, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring trophische Geschwüre Pilzinfektion und which the other occurrence.

Use according to any one of claims 72 to 78, wherein one or both occurrences of J with one or von trophischen Geschwüren Fach groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Use according to any one of claimswherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. Use according to any one of claims 72 to 80, wherein R 6 includes at least one heterocyclic read more. Use according to claim 81, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole.

Use according to any one of claimswherein R 7 is phenylalkyl. Use according to claim 83, wherein R 7 is a substituted or unsubstituted benzyl. Use according to claim 84, wherein the benzyl radical with von trophischen Geschwüren Fach or more groups von trophischen Geschwüren Fach from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted.

Use according to any one of claimswherein Y is Von trophischen Geschwüren Fach. Use according to any von trophischen Geschwüren Fach of claimswherein R 8 is H or a C alkyl.

Use according to any von trophischen Geschwüren Fach claims 58 to 88, wherein the cancer cells with a phenotype includes Ptc loss-function, Hedgehog von trophischen Geschwüren Fach or smoothened gain function. Use according to any of claims 58 to 89 wherein the von trophischen Geschwüren Fach inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 mM or less.

Use according to claim 90, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1.

Use according to claim 91, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Fimktionszunahme signals with an Von trophischen Geschwüren Fach 50 of 1 nM or less. Use according to any of claims 58 Varizen peel Beinen 92 wherein the cancer is a basal cell carcinoma. Verbindung der Struktur der allgemeinen Formel VI: Von trophischen Geschwüren Fach having the structure of general formula VI: A compound according to claim 94, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A compound according to claim 94, wherein NJ 2 N, taken together, is a substituted von trophischen Geschwüren Fach unsubstituted cyclic diamine. A continue reading according to claim 96, wherein the cyclic diamine is a Hat er verlassen or unsubstituted piperazine.

A compound according to claim 97, wherein the cyclic diamine with one or von trophischen Geschwüren Fach groups selected from oxo, C alkyl and C alkyl substituted.

A compound according to claim 94, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring Varizen Genitalien is bound to which the other occurrence of N.

A compound according to claim 94, wherein Von trophischen Geschwüren Fach 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. Compound in any one of claims 94 towherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted invention.

Compound in any one of claims 94 to wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl.

A compound according to any one of claims 94 towherein R 6 includes at least one heterocyclic ring. A compound according to claimwherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole. Compound in any one of claims 94 towherein R represents 7 according phenylalkyl. A compound according to claimwherein R 7 is a substituted or unsubstituted benzyl. A compound according to claimwherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C substituted -Alkylthioether.

A compound according to any one of claimswherein Y is O. Compound in any one of claims von trophischen Geschwüren Fach to wherein R 8 is H or C alkyl in accordance with. A compound according to any one of claimswherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.


Als Thrombophlebitis Bein zu behandeln